Daniel C. Link, MD

Daniel C. Link, MD

Alan and Edith Wolff Endowed Professor; Chief, Division of Oncology; Deputy Director, Alvin J. Siteman Cancer Center

Address:
Division of Oncology
Mail Stop 8007-0057-07
Washington University
660 South Euclid Avenue
St. Louis, MO 63110

Room 729, Southwest Tower (office)
Room 7

Admin:
Lindsay Thurston
lindsaythurston@wustl.edu

Clinical Interests
  • Hematopoietic stem cell transplantation
  • Leukemia
  • Neutropenia
Research Interests
  • Stem cells
  • Stem cell niche
  • Leukemogenesis
Research

Our current research is focused on two general areas: characterizing the regulation of hematopoietic niches in the bone marrow under homeostatic and stress conditions and defining the molecular pathogenesis and treatment of leukemias. Cutting edge genomic, transgenic, and imaging approaches are being used in this research. The Link laboratory emphasizes a collaborative research environment and places a priority on the career development of its trainees.

Highlights of current research include the following:

  1. How do hematopoietic stem cells carrying mutations of TP53 transform to leukemia
  2. How does transforming growth factor beta signaling contribute to the pathogenesis of myeloproliferative neoplasms
  3. What are metabolic changes associated with T cell leukemia and can they be exploited to develop novel targeted therapies.
  4. What role does ribosome (nucleolar) stress play in the pathogenesis of T cell leukemia
  5. What are the bone marrow stromal (niche) signals that regulate hematopoiesis and do alterations in these signals contribute to hematopoietic malignancies
Link Lab
Profiles (publications)

Biosketch

Education

  • 1985: MD, University of Wisconsin-Madison, Madison, WI
  • 1981: BS, University of Wisconsin-Milwaukee, Milwaukee, WI

Post-Graduate Training

  • 1992-1988: Hematology-Oncology Fellow, Washington University Medical Center, St. Louis, MO
  • 1988-1986: Assistant Resident in Medicine, Barnes Hospital, St. Louis, MO
  • 1986-1985: Intern in Medicine, Barnes Hospital, St. Louis, MO
  • 1984: Medical Research, NCI summer training award, NIH, Baltimore, MD

Academic Positions

  • present-2022: Deputy Director, Alvin J. Siteman Cancer Center, Washington University Medical School, St. Louis, MO
  • present-2022: Chief, Division of Oncology, Washington University Medical School, St. Louis, MO
  • present-2008: Professor, Departments of Medicine and Pathology & Immunology, Washington University Medical School, St. Louis, MO
  • 2008-2003: Associate Professor, Department of Medicine, Washington University Medical School, St. Louis, MO
  • 2003-1996: Assistant Professor, Departments of Medicine and Pathology & Immunology, Washington University Medical School, St. Louis, MO
  • 1996 -1993: Instructor, Department of Medicine, Washington University Medical School, St. Louis, MO

University & Hospital Appointments & Committees

  • Senior Leadership Committee, Siteman Cancer Center
  • Co-program leader, Hematopoietic Development and Malignancy Program, Siteman Cancer Center
  • Markey Pathway Admissions and Steering Committee, Washington University
  • MA/MD Program Admissions and Steering Committee, Washington University
  • DBBS Faculty Membership Committee, Washington University
  • Chair, Siteman Cancer Center RFA Grant Review Committee, 2013, 2014
  • McKinley Research Building Planning Committee, 2015
  • ICTS Pilot Program Committee Advisor, 2016-2018
  • Chair, Search Committee for Chief of Pediatric Hematology-Oncology, Washington University
  • Chair, Distinguished Faculty Awards Committee, Department of Medicine, Washington University, 2017
  • Member, Search Committee for Chair of the Department of Pathology & Immunology, Washington University
  • Member, Basic Science/Translational Research Program Committee, Department of Medicine, Washington University
  • Clinical Cancer Building Visioning Committee
  • Department of Medicine Research Space Planning Committee
  • Barnes Jewish Hospital Investigator Program Selection Committee
  • Siteman Cancer Center Shared Resource Advisory Committee
  • Chair, Siteman Cancer Center Strategic Planning Committee for Hematopoietic Malignancies

Board Certification

  • 1990: Hematology
  • 1989: Internal Medicine

Honors & Awards

  • present-2020: Standing Member, NIH Hemostasis, Thrombosis, Blood Cells, and Transfusion Medicine Study Section
  • 2021: Distinguished Faculty Award for Graduate Student Teaching, Washington University
  • 2020-2017: Standing Member, NIH Molecular and Cellular Hematology Study Section
  • 2016: Chair, Myeloid Biology Scientific Committee, American Society of Hematology
  • 2015: Washington University School of Medicine Alumni Faculty Achievement Award
  • 2012: Distinguished Faculty Award for Graduate Student Teaching, Washington University
  • 2010: Outstanding Faculty Mentor Award, Washington University
  • 2010: Member, American Society of Hematology Scientific Subcommittee on Myeloid Biology
  • 2009: Election to the Association of American Physicians
  • 2009: Alan and Edith Wolff Endowed Professor
  • 2009: Executive Committee of the Severe Congenital Neutropenia International Registry
  • 2005: Medical Advisory Board of the Severe Congenital Neutropenia International Registry
  • 2000: Election to American Society of Clinical Investigation
  • 1998: 28th Mallinckrodt Scholar, Edward Mallinckrodt, Jr. Foundation
  • 1993: McDonnell Scholar in Molecular Oncology; Washington University Medical Center, St. Louis, MO
  • 1984: NCI Summer Training Award; National Institutes of Health, Bethesda, MD
  • 1984: Alpha Omega Alpha; University of Wisconsin-Madison Medical School, Madison, WI
  • 1984-1981: Outstanding Achievement Award by Promotion’s Committee; University of Wisconsin-Madison Medical School, Madison, WI
  • 1982: Academic Excellence Award (top 2% of class); University of Wisconsin-Madison Medical School, Madison, WI
  • 1981: Kurt H. Vanselow Undergraduate Research Scholarship; University of Wisconsin-Milwaukee, Milwaukee, WI
  • 1981: The American Institute of Chemists’ Student Award; University of Wisconsin-Milwaukee, Milwaukee, WI
  • 1981: Phi Beta Kappa; University of Wisconsin-Milwaukee, Milwaukee, WI

Editorial Responsibilities

  • present-2013: Editorial Board, Leukemia
  • present-2013: Editorial Board, Blood
  • 2007-2002: Editorial Board, Experimental Hematology
  • 2007-2002: Editorial Board, Blood

Professional Societies

  • Alpha Omega Alpha
  • American Society of Hematology
  • American Society of Clinical Investigation
  • International Society for Experimental Hematology
  • Association of American Physicians

Board Memberships

  • Medical Advisory Board, Severe Congenital Neutropenia International Registry
  • Executive Committee, Severe Congenital Neutropenia International Registry
  • External Advisory Committee, NASA Specialized Center on Research in Radiation Carcinogenesis
  • External Advisory Board, Albert Einstein Cancer Center
  • External Avisory Board, Memorial Sloan Kettering SPORE in Renal Cancer
  • Internal Advisory Board, SPORE in Pancreatic Cancer, Washington University
  • Internal Advisory Board, Breast Cancer Metastasis PO1, Washington University
  • External Advisory Board, Northwestern University SPORE in Leukemia, 2017
  • Internal Advisory Board, Translational Research Center in Thrombotic and Hemostatic Disorders, U54, Washington University
  • Internal Advisory Board, SPORE in Breast Cancer, Washington University
  • Internal Advisory Board, Washington University PO1 on the Bone Marrow Microenvironment in Breast Cancer
  • Chair, External Advisory Board, Rochester University PO1 on the MDS Niche
  • External Advisory Board, Ohio State University PO1 “Retrovirus Models of Cancer”
  • Internal Advisory Board, SPORE in Endometrial Cancer, Washington University
  • External Advisory Board, SPORE in Leukemia, the Ohio State University
  • Chair, Internal Advisory Board, SPORE in Prostate, Washington University
  • External Advisory Board, Indiana University Simon Cancer Center
  • Chair, Internal Advisory Board, PO1 on DNA Repair in Myeloid Neoplasms, Washington University
  • Review panel, Damon Runyon Clinical Investigator Award, Damon Runyon Cancer Research Foundation
  • Chair, Internal Advisory Board, PO1: “Dissecting Stromal-Tumor Interactions to Enhance Chemoimmunotherapy”, Washington University
  • External Advisory Board, SPORE in Leukemia, Harvard University